OCT3 promoter haplotype is associated with metformin pharmacokinetics in Koreans
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HMOX1 Gene Promoter Polymorphism is Not Associated with Coronary Artery Disease in Koreans
BACKGROUND The heme oxygenase-1 gene (HMOX1) promoter polymorphisms modulate its transcription in response to oxidative stress. This study screened for HMOX1 polymorphisms and investigated the association between HMOX1 polymorphisms and coronary artery disease (CAD) in the Korean population. METHODS The study population consisted of patients with CAD with obstructive lesions (n=110), CAD with...
متن کاملAngiotensinogen Promoter B-Haplotype Associated With Cerebral Small Vessel Disease
Helena Schmidt, Yurii S. Aulchenko, Natascha Schweighofer, Reinhold Schmidt, Sasa Frank, Enhances Basal Transcriptional Activity Angiotensinogen Promoter B-Haplotype Associated With Cerebral Small Vessel Disease Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2004 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Aven...
متن کاملPCSK9 Associated Promoter Methylation Status in Patients with Hyperlipidemia
Background and purpose: Hyperlipidemia is one of the main risk factors for coronary artery disease and is defined as abnormal elevation of lipids or lipoproteins in the blood. Pcsk9 is the ninth member of the proprotein convertase family that binds to the LDLR on the surface of the hepatocyte, leading to degradation of LDLR in lysosomes which could cause hyperlipidemia. The present study aimed...
متن کاملA common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss.
We sought to verify whether variation in the promoter of the gene encoding placental anticoagulant protein annexin A5 (ANXA5) represents a risk factor for recurrent pregnancy loss (RPL). Sequence analysis of 70 German RPL patients, all known to carry neither factor V Leiden nor a prothrombin mutation, revealed four consecutive nucleotide substitutions in the ANXA5 promoter, which were transmitt...
متن کاملHaplotype-tagging interleukin-10 promoter polymorphism is associated with reduced risk of retinal artery occlusion
PURPOSE Pro- and anti-inflammatory cytokines, including interleukin 10 (IL-10), play an essential role in atherogenesis. Increased IL-10 production has been found among carriers of the IL10 [TCATA] haplotype, which is formed by five polymorphisms at position -3575, -2763, -1082, -819, and -592 in the promoter region of the IL10 gene. Due to linkage disequilibrium, the presence of the [TCATA] ha...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-35322-6